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姓 名: | ××× | 性别: | 女性 | 年龄: | 64岁 |
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CHENYINQIAO 离线
shihong4699 离线
lilymeining 离线
1 luo photos like papillary lesion, but 11 luo morphologic and IHC features are classic 腺样囊性癌.
morphology: cribriform, glandular, cylindromatous growth patterns. main DDX: Collagenous spherulosis.
Cells: Ductal epithelial and myoepithelial cells
Basement membrane materials.
IHC:
P63 stains myoepithelial/basaloid components
CK8 stains ductal epithelial cells
ER/PR negative in ductal epithelial cells
Her2 negative (often)
CD117 positive (useful marker)
P53 mutation occur more frequently in high grade tumor
Ki67 stain 15-25% cells
PSA stain base memberane material